Medication-assisted treatment provides an evidence-based path to recovery by combining FDA-approved medications with therapy. This approach helps ease symptoms stemming from withdrawal, reduce cravings, and support long-term sobriety, making it an effective option for those struggling with substance use disorders.
What is medication-assisted treatment?
Medication-assisted treatment (MAT) is an evidence-based approach that combines the use of FDA-approved medications with behavioral therapy to treat substance use disorders. Rather than relying solely on counseling or detox, MAT addresses both the physical and psychological components of addiction. By easing withdrawal symptoms, lowering cravings, and providing a safer pathway to recovery, MAT helps patients stabilize their lives while building long-term resilience against relapse.
The U.S. Department of Health and Human Services and the Substance Abuse and Mental Health Services Administration (SAMHSA) recognize MAT as one of the most effective treatment pathways for opioid use disorder (OUD) and alcohol addiction. Many patients begin MAT during detox, but it can continue throughout recovery as part of a broader opioid treatment program. Research has demonstrated that MAT can lower mortality rates, reduce criminal activity linked to the abuse of drugs, and increase overall treatment success.
How MAT combines medication and therapy
MAT is not just about prescribing medication. It is designed to be used in conjunction with counseling and behavioral therapy, creating a holistic model that targets both the brain and the behavior behind substance use. While medications help restore balance in brain chemistry, therapy addresses the root causes of addiction, such as trauma, stress, or mental health disorders.
Therapies often included in MAT programs are cognitive behavioral therapy (CBT), contingency management, motivational interviewing, and 12-step facilitation. Together, these approaches help patients develop healthier coping mechanisms, reduce risk factors like opioid misuse, and strengthen recovery outcomes. Many providers, from primary care practitioners to specialized treatment programs, offer MAT as a core part of their services.
Types of medications used in MAT
The cornerstone of MAT is the use of three FDA-approved medications for treating opioid addiction: methadone, buprenorphine, and naltrexone (or Suboxone). Each medication works differently but shares the same goal: helping patients reduce cravings, stabilize, and prevent relapse.
- Methadone. A full opioid agonist that helps reduce withdrawal symptoms and cravings by interacting with opioid receptors in a controlled way. Dispensed at licensed treatment programs, particularly effective for patients with severe opioid dependence or long-term heroin use.
- Buprenorphine. A partial opioid agonist that relieves withdrawal without producing the euphoric high associated with opioid misuse. Often prescribed in the form of Suboxone (a combination of buprenorphine and naloxone), it can be administered in office-based settings by licensed practitioners.
- Naltrexone. An opioid antagonist that blocks the effects of opioids at the receptor level, preventing euphoria and reducing cravings. Available in pill form or as an extended-release injectable suspension (Vivitrol), it is often used after detox to support staying clean.
For alcohol use disorder, acamprosate and disulfiram may also be prescribed. These medications reduce cravings and deter drinking through different mechanisms.
You can overcome addiction. Reach out to discover:
What MAT can help with
Medication-assisted treatment is primarily used to treat opioid use disorder (OUD) and alcohol use disorder, but it can also help individuals struggling with other forms of substance abuse. MAT is particularly helpful in reducing the risk of opioid overdose, supporting patients with a history of heroin or prescription drug addiction, and helping those at risk of relapse after detox.
By reducing cravings and stabilizing brain chemistry, MAT allows patients to focus their efforts on rebuilding their lives, maintaining employment, repairing family relationships, and addressing mental health challenges. It provides different treatment paths depending on individual needs, meaning that more patients receive care tailored to their specific disorder.
How medication-assisted treatment benefits those with substance use issues
Patients receiving MAT often report improvements not just in their recovery, but in overall quality of life. Benefits include:
- Reduced cravings and other issues, which makes staying free of drugs more achievable
- Lower risk of opioid overdose and related mortality
- Greater likelihood of staying engaged in treatment programs
- Reduced criminal offenses connected to the previous use of drugs
- Improved ability to maintain employment and stable housing
- Better management of co-occurring conditions, from hepatitis C and diabetes to mental health disorders
The Centers for Disease Control and Prevention (CDC) has highlighted MAT as an effective treatment that promotes health and prevents disease progression related to opioid dependence.
The role of MAT in reducing cravings and the threat of relapse
One of the greatest challenges in recovery is managing cravings. For many patients, cravings can create significant barriers to staying clean. MAT reduces these challenges by using medications that stabilize the brain’s opioid receptors. This makes relapse less likely and helps patients avoid the dangerous cycle of drug use.
By blocking euphoric effects and blunting cravings, medications like buprenorphine and naltrexone help individuals remain engaged in their recovery. Studies have demonstrated that MAT lowers relapse rates compared to counseling alone, making it a key part of effective treatment.
How MAT improves long-term sobriety
MAT is not a short-term fix; it aids in recovery for months or even years. Long-term use of MAT, especially when paired with ongoing behavioral therapy, increases the chances of staying clean. Patients are able to focus on personal development, employment, education, and rebuilding relationships rather than being caught in the vicious cycle of drugs.
Providers determine dosage and duration on a case-by-case basis, but research shows that MAT continued for at least 12 months is associated with the strongest outcomes. Over time, patients may taper off medication under medical supervision, but many benefit from longer-term maintenance as part of their treatment plan.
Free Insurance Check
Our rehab center accepts most insurance plans.
Check if your insurance will cover the cost of treatment by filling out our confidential insurance form. We accept most insurance plans.
Effectiveness of medication-assisted treatment
MAT has been studied extensively and has demonstrated efficacy across populations. Comparative effectiveness research shows that patients on MAT have higher retention rates, lower opioid use, and decreased mortality compared to those receiving non-medicated treatment.
In fact, the National Institutes of Health and SAMHSA identify MAT as the gold standard for treating opioid use disorder. Patients receiving MAT are more likely to achieve freedom from drugs, maintain employment, and reduce criminal activity. This makes MAT not just an effective treatment for individuals but a public health solution that benefits communities.
MAT success rates and patient outcomes
Success rates for MAT vary depending on factors like patient engagement, length of treatment, and integration with counseling. However, research consistently shows that MAT increases the likelihood of recovery compared to abstinence-only programs.
- Many patients experience a 50% or greater retention within the program
- Long-term studies show lower mortality rates among patients (particularly veterans) engaged in MAT compared to those not receiving treatment.
- MAT improves social outcomes, such as reduced criminal activity, better family functioning, and stronger employment stability.
Though stigma and misconceptions remain, MAT has demonstrated effectiveness in helping individuals reclaim their lives.
Rehab might feel like a big step, but remember why you're here—you’re looking for a way forward. We can help.
Medication-assisted treatment FAQs
How does medication-assisted treatment work?
MAT works by combining medications such as methadone and buprenorphine that stabilize brain chemistry with counseling that addresses underlying behaviors. These medications minimize cravings, while therapy helps patients develop new coping skills. Together, these approaches create a strong foundation for recovery.
What medications are most commonly used in MAT?
The three medications most often used are methadone, buprenorphine, and naltrexone. Each works differently to reduce cravings, block euphoria, or ease symptoms. For alcohol use disorder, acamprosate and disulfiram may also be prescribed.
Is MAT safe for long-term recovery from opioid use disorder?
Yes. Multiple studies have demonstrated that MAT is safe and effective when monitored by trained providers. Long-term use can reduce relapse, lower the threat of overdose, and guide recovery. Doses of buprenorphine, naltrexone, and methadone are carefully given and adjusted by practitioners to ensure safety.
Does medication-assisted treatment replace one drug with another?
No. Unlike illicit drug use, MAT medications are carefully prescribed, monitored, and dosed to reduce dependence. They stabilize the brain, allowing patients to focus on therapy and recovery without the highs and lows of misuse. MAT is a medically guided treatment and not a substitution.
How long do people usually stay in MAT programs?
The duration of MAT depends on individual needs. Some patients benefit from MAT for months, while others require years of therapy. Providers work with patients to determine when tapering or discontinuation is safe. Research shows longer engagement often leads to stronger outcomes.
Red Ribbon Recovery offers MAT and other therapies, call today for help
At Red Ribbon Recovery, we understand that every recovery journey is unique. That’s why we offer medication-assisted treatment Colorado residents can trust, along with a full range of therapy options. Our licensed primary care providers prescribe the three medications: buprenorphine, methadone, and naltrexone, in conjunction with counseling and behavioral therapy to ensure comprehensive support.
If you or a loved one is struggling with opioid use disorder, alcohol dependence, or another form of substance use disorder, our team is here to help. We provide treatment access tailored to your needs, guided by evidence-based care and compassionate providers.
Call (303) 219-3980 today to speak with a treatment specialist and learn more about our drug and alcohol detox programs, insurance verification, and admission pathways. Recovery is possible—with the right support, treatment, and care, you can build a healthier, substance-free future.
We are here to help you or a loved one find addiction treatment near you.
Admitting you have a substance abuse problem and asking for help is not always easy. If you or a loved one are struggling with drug addiction, alcohol addiction or another substance use disorder, help is available. Call SAMHSA’s National Helpline at (303) 219-3980 to learn about resources in your area or reach out to our team for personalized treatment.
Treatment Center Reviews
Bridget LaRocco
I have been to this facility twice now, for Laser Hair removal and Botox. I saw Kim 2 times now for laser and she has been great, she made me feel really comfortable and…
Bridget LaRocco
I have been to this facility twice now, for Laser Hair removal and Botox. I saw Kim 2 times now for laser and she has been great, she made me feel really comfortable and…
Bridget LaRocco
I have been to this facility twice now, for Laser Hair removal and Botox. I saw Kim 2 times now for laser and she has been great, she made me feel really comfortable and…
Sources
- World Health Organization: WHO. (2024, May 27). Post-traumatic stress disorder. https://www.who.int/news-room/fact-sheets/detail/post-traumatic-stress-disorder#:~:text=Around%2070%25%20of%20people%20globally,following%20sexual%20violence%20(1).
- What is Methadone? Side Effects, Treatment & Use. (n.d.). https://www.samhsa.gov/substance-use/treatment/options/methadone
- What is Buprenorphine? (n.d.). Psychiatric Research Institute. https://psychiatry.uams.edu/clinical-care/outpatient-care/cast/buprenorphine/
- Singh, D., & Saadabadi, A. (2023, May 30). Naltrexone. StatPearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK534811/
- Feelemyer, J., Jarlais, D. D., Arasteh, K., Abdul‐Quader, A. S., & Hagan, H. (2013). Retention of participants in medication‐assisted programs in low‐ and middle‐income countries: an international systematic review. Addiction, 109(1), 20–32. https://doi.org/10.1111/add.12303
- Ching, J. H., Owens, D. K., Trafton, J. A., Goldhaber‐Fiebert, J. D., & Salomon, J. A. (2021). Impact of treatment duration on mortality among Veterans with opioid use disorder in the United States Veterans Health Administration. Addiction, 116(12), 3494–3503. https://doi.org/10.1111/add.15574
About the content
Written by: Carli Simmonds. Carli Simmonds holds a Master of Arts in Community Health Psychology from Northeastern University. From a young age, she witnessed the challenges her community faced with substance abuse, addiction, and mental health challenges, inspiring her dedication to the field.
Medical reviewed by: Jodi Tarantino, LICSW. Jodi Tarantino is an experienced, licensed Independent Clinical Social Worker (LICSW) and Program Director with over 20 years of experience in Behavioral Healthcare. Also reviewed by the RRR Editorial team.
Red Ribbon Recovery is committed to delivering transparent, up-to-date, and medically accurate information. All content is carefully written and reviewed by experienced professionals to ensure clarity and reliability. During the editorial and medical review process, our team fact-checks information using reputable sources. Our goal is to create content that is informative, easy to understand and helpful to our visitors.
